Diabetes Subtypes and Precision Medicine

A new study on early-onset T2D identifies a renal-predominant subgroup using routine labs, and highlights FIB-4 limitations for liver fibrosis screening in young adults. Earlier precision medicine signals show type 2 diabetes operates differently across weight profiles: lean Africans have insulin deficiency, overweight patients have resistance, leading to different complication patterns. A new study confirms this, showing current treatments targeting resistance may be harming lean patients. Prediabetes reversal through lifestyle (muscle, fiber, meal timing) is reinforced. The 'metabolically healthy obesity' paradox challenges binary views, affecting ~300M people globally.