Metabolic Health Digest

Oestrogen decline in perimenopause and menopause can raise LDL cholesterol, reduce HDL protection, and increase triglycerides.

• Heart disease risk...

Post hoc analysis shows HDL cholesterol levels predict major cardiovascular events in statin-treated patients. This relationship holds even when LDL reaches very low levels, though it does not automatically make HDL a treatment target.

Clinical guidelines stress obesity as chronic, requiring maintenance plans to avoid weight regain after stopping GLP-1 drugs.

Real-world Dutch data...

Obesity reflects diet-driven functional gut microbiota disruption more than specific taxa or excess calories alone, impairing SCFA production, bile...

A man with obesity, type 2 diabetes, and acne may carry higher metabolic risk if his sister has PCOS, prompting clinicians to view these as possible...

Real-world data from newly diagnosed type 2 diabetes patients reveals mixed outcomes with early insulin plus metformin versus metformin alone.

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Once-weekly insulin is called a huge deal for patients with diabetes, as it could improve treatment convenience and adherence by cutting daily...

A new multidisciplinary cross-sectional survey explores physicians' perceptions and referral patterns for bariatric surgery among overweight and obese...

UK sugar rationing ended in 1953, creating a natural experiment separating genetically similar groups by early-life sugar access.

• People with...

Menopause transition alters lipid profiles, raising cardiovascular risk, yet hormone therapy is not indicated for dyslipidemia. Statins remain first-line pharmacologic therapy once lifestyle interventions prove insufficient.

Mouse studies reveal ovaries don't simply shut down after reproduction. Instead they undergo ongoing molecular shifts, losing reproductive identity...

• Lean mass loss of 25-39% in GLP-1 trials includes water, organs, and connective tissue—not just skeletal muscle, as DEXA scans confirm.
• Fat still...

Hypothyroidism raises total and LDL cholesterol through slowed lipid metabolism, with stronger effects in overt disease than subclinical...

People with overweight or obesity rank weight-loss efficacy, CV risk reduction, and oral dosing as top factors when selecting obesity medications....

Supplements offer limited help for blood sugar but cannot replace core habits.

• Foundational steps first: Prioritize fiber-rich meals, a short walk...

36mg剂量比12mg额外减重2.62%体重、2.31kg，并改善腰围、HbA1c及收缩压。

安全性方面，两剂量治疗 emergent不良事件、停药率及胃肠道反应无显著差异。

分析支持滴定至36mg维持剂量以最大化获益，且未见临床担忧的不良事件增加。

Blood sugar management involves more than food choices—circadian rhythms influence insulin sensitivity, glucose tolerance, and hormone patterns...

FDA批准Kerendia（非奈利酮）用于1型糖尿病相关慢性肾病成人患者，FINE-ONE研究显示6个月内尿蛋白较安慰剂多降低25%，有助于减缓肾损伤。每日一次口服，需监测血钾并注意药物相互作用。

Sandy Struss's first CGM sensor revealed a hidden post-lunch spike after her sandwich and soup, triggering rage bolusing and a crash that left her...

Intermittent fasting may aid weight and blood sugar control in type 2 diabetes but poses serious risks for some.

• Hypoglycemia danger: Episodes rise...