Metabolic Health Digest

• Deal scale: Genentech pays $190M upfront for HM17321, up to $2.3B total
• Mechanism: UCN2 analog activates CRHR2 to preserve muscle while reducing...

Poor sleep is amplifying metabolic problems in two key groups.

• Statin users face sleep changes from common lipid-lowering agents like...

The real drivers of metabolic decline aren't sugar itself, but repeated daily patterns.

• Frequency matters most: Occasional treats barely register,...

Women frequently receive standard tests yet face dismissed symptoms and unaddressed metabolic risks like elevated cholesterol and prediabetes.
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Employers weigh high upfront costs against uncertain returns when deciding on GLP-1 coverage for weight loss.

• Coverage trends: Just 36% of...

Aligning sleep, meal timing, and daily routines supports metabolic health through circadian rhythms.

• Follow a Mediterranean-style diet with...

A Swedish study of 2,981 adults aged 60+ found longer meal intervals (14–24 hours) linked to faster chronic disease accumulation over 15 years,...

• OSSI and ESI consensus labels obesity a chronic disease driven by genetic, metabolic, endocrine and environmental factors beyond personal control.
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Women with prior GDM face 20–50% risk of type 2 diabetes within five years postpartum. A 4-year lifestyle intervention (diet counseling, weight loss,...

A systematic review of 104 trials found curcumin modestly aids metabolic syndrome markers.

• Glycemic gains: Small drops in fasting glucose and...

A new study reveals type 2 diabetes works through opposing pathways depending on weight.

• High-BMI patients develop the disease mainly via insulin...

Eli Lilly's Foundayo (orforglipron) brings the first oral GLP-1 option to European patients, offering once-daily dosing without food or water...

Diabetes distress stands out as a central driver of psychosocial challenges in type 1 diabetes, emphasizing the urgent need to integrate mental health support into routine T1D care.

Obesity is increasingly viewed as a systemic disease involving interconnected molecular and clinical pathways.

• TOFA boosts fat oxidation in obese...

Your body's internal clock and sleep quality drive metabolism in distinct but connected ways.

• Liver clock precision: Proteins regulating metabolism...

• Lipfendra (enlicitide), the first oral PCSK9 inhibitor, gained FDA approval in July 2026 for LDL reduction of 56-59% on top of statins, but...

A Central Florida doctor urges looking beyond the scale when considering GLP-1 medications.

• These drugs mimic hormones to curb appetite and support...

Considering weight loss surgery? These answers address common concerns for candidates.

• Eligibility: BMI of 35+ or 30-34.9 with conditions like...

Type 2 diabetes cases among US youth aged 10-19 rose nearly 10-fold between 2002 and 2023, serving as a stark wake-up call for parents to prioritize healthy eating and daily physical activity.

• GLP-1 angle: Small 2026 study found semaglutide produced 19 kg median weight loss and 52% androgen drop in PMOS women, with some menstrual...