Midlife and women’s brain health rising as a prevention frontier
Key Questions
Why do standard Alzheimer's tests miss risks in women?
MMSE tests mask mild cognitive impairment in women (n=332), as their brains compensate via MRI patterns but show steeper AD decline later.
What blood test predicts dementia in women long-term?
The p-tau217/Aβ blood test predicts dementia 25 years ahead (n=2,766, AUC 0.93), highlighting women's midlife risks.
How do menopause and oophorectomy affect women's brain health?
Menopause and oophorectomy increase dementia risk; HRT, fertility factors, and equity-focused mobile screening address midlife prevention disparities.
Meno/ooph risk; p-tau217/Aβ 25-yr n=2,766; MMSE masks MCI in women (n=332 MRI compensation/steeper AD decline). HRT/fert/equity/mobile/early-onset disparities.
Sources (2)
Updated Apr 9, 2026