Dementia Prevention Digest

Blocking PD-1/PD-L1 in an Alzheimer’s mouse model restored microglial homeostasis, cleared smaller amyloid plaques, and reduced neuronal...

Protective genes may help some APOE4 carriers avoid Alzheimer's entirely, showing that carrying the variant does not determine one's future....

Medication side effects and delirium frequently cause dementia misdiagnoses that alter lives.

• A bank clerk diagnosed with Alzheimer’s regained...

Can HRT protect against dementia? Research leaves the question unresolved.

Key factors:

• Timing and formulation appear critical to any potential...

Alzheimer's disease faces a major therapeutic obstacle because the blood–brain barrier severely restricts central nervous system access. Nose-to-brain...

In early symptomatic cognitive impairment consistent with AD, plasma biomarker results may discord with the clinical diagnosis when Lewy body...

Researchers are studying families with rare genetic predispositions to dementia to explore new ways to predict, treat, or prevent Alzheimer's. This...

A common inflammation marker already in routine bloodwork shows promise for flagging future dementia risk, yet remains far from diagnostic.

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Patients and families should grasp the basic mechanism of these anti-amyloid treatments.

• Natural antibodies recognize and bind to specific...

The UK is investing £80 million across nine technologies to diagnose dementia faster, targeting 92% of patients within 18 weeks of referral—up from...

Brain-health recommendations developed mainly in Western groups delivered clear cognitive gains only after cultural adaptation in the LatAm-FINGERS...

California's new FTD registry requires providers to report every diagnosis, building a clearer picture of the disease's impact.

• Surveillance boost:...

Could subtle changes in walking reveal brain alterations decades before dementia symptoms appear?

New research finds brains begin changing long...

An 18-month wait from first GP concerns to diagnosis left one family frustrated and financially strained, highlighting systemic barriers for atypical...

Is Alzheimer’s truly entirely avoidable through lifestyle alone?

• Nehls argues it stems from stalled hippocampal neurogenesis due to shortfalls in...

African green monkeys given synthetic amyloid-beta still performed normally on memory tasks a year later despite brain changes, pointing to possible...

• 极低水平eMTBR-Tau现可通过超敏免疫测定在血浆中检测，揭示tau缠结病理
• 抗淀粉样蛋白治疗后，34种蛋白轨迹各异：部分趋向正常，部分偏离参考水平
• 血液检测正转向多维度疾病监测，但距离常规筛查和个体化决策仍有差距

阿尔茨海默病诊断需整合病史、认知评估、共病、影像与生物标志物等多维度信息，而非依赖单一血液检测结果。 这有助于避免将实验室数据直接等同于个人未来命运。

教育可能调节生物标志物与皮质厚度的关联，相同生物学变化未必对应相同临床风险。

Low-dose aspirin showed a 70% lower dementia risk in older adults with a high platelet-related genetic score, pointing toward future precision...