Experimental Brain Measures Show Promise for Early Alzheimer’s Research

A Stanford-associated resting-state fMRI score (ARC) was associated with later cognitive decline and amyloid accumulation in cognitively normal participants followed for up to 12 years. A new SuperAgers connectome study found an Alzheimer’s-like pattern in about a quarter of apparently healthy older adults and linked patterns with differing later trajectories; a separate 116-person study associated flatter, lower-amplitude deep-sleep waves with the Alzheimer’s continuum. These remain preliminary research signals, not validated personal prediction or screening tools.