Genomics foundation models expand while biosecurity risks intensify

Evo 2, GPN-Star, AlphaGenome-related resources, splice-focused systems including SpliceAI2, regulatory-genomics models, and AI-assisted protein and genome-editing design are broadening genome analysis and biological engineering. Functional validation, off-target and delivery assessment, safety, privacy, ancestry representation, biosecurity, and clinical utility remain unresolved; recent reading adds no confirmed translational breakthrough.