NeuroCIM Research Digest

This study connects plasma tau markers to symptoms, not just diagnosis. Earlier work showed these species discriminated autopsy-confirmed AD, but did...

Unusually high or low hemoglobin may signal higher dementia risk, and experts say it may reflect underlying conditions rather than directly cause...

The core bet is that age-related peripheral immune dysfunction contributes to Alzheimer's progression, and that the systemic protective response may...

A new Research Topic is calling for submissions on lipid signaling in aging and neurological disease. It is not reporting findings.

• Sphingolipids...

PLOS Biology's Associate Editor Taylor Hart makes the case for studying neurodegeneration in its physiological context. Disease processes may damage...

Karolinska Institutet researchers tracked 372 dementia-free older adults with blood tests and brain MRIs over time. Their key links:

• Tau and the...

The ALTITUDE-AD trial of sabirnetug did not meet its primary cognitive and functional endpoint at either dose, and Acumen plans to cease...

Kingston Health Sciences Centre is offering newly approved Alzheimer's disease-modifying drugs, so patients in southeastern Ontario who once travelled...

Lewy body dementia is an umbrella term for dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). They share features like...

Plasma pTau217 is a strong marker of amyloid positivity, but this GARD cohort study suggests pairing it with other markers adds information:

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A new Frontiers research call invites work on a gap the authors describe as the molecular routes from external neurotoxic challenges to neuronal loss,...

Lithium's neuroprotective properties are thought to be attributed to inhibiting GSK-3β and IMPase, along with regulating downstream pathways. This...

The amygdala is reported to be affected early in several neurodegenerative disorders. The article's title frames the topic as a path from amygdaloid...

This article reports that tau and amyloid show distinct relationships with cognitive outcomes, within a framework where amyloid-β plaques accumulate...

A new blood test can detect brain changes linked to Alzheimer's, and more patients are asking about it. The report's limits matter as much as its...

Memantine is a noncompetitive, moderate-affinity NMDA receptor antagonist that reduces excitotoxicity by inhibiting overactivated NMDA receptors.

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The Foundation of the American Society of Neuroradiology and the Alzheimer's Association jointly offer this grant to support early-stage pilot...

The article presents Porphyromonas gingivalis, a bacterium that colonizes periodontal pockets, as a possible contributor to Alzheimer's. It notes...

A special seminar, Understanding the Role of Synapses in Dementias, features Tara Spires-Jones, Professor of Neurodegeneration at the University of...

The AT(N) framework sorts biomarkers by the biology they reflect:

• Amyloid (A): A lower Aβ42/40 ratio is commonly associated with cerebral amyloid...