Blood biomarkers show promise for Alzheimer’s staging and preclinical progression

Plasma eMTBR-tau has exploratory stage and MCI-conversion findings, but only 6 of 40 MCI participants converted, requiring larger external validation. A conference cohort of 372 dementia-free older adults found p-tau217 and p-tau181 associated with hippocampal loss and GFAP with broader volume changes; these associations do not establish screening benefit or clinical utility.