Tau seeding, burden, and therapeutic signals track Alzheimer’s pathology

A large PET comparison reports higher, more widespread cortical tau and faster accumulation in early- than late-onset Alzheimer’s, reinforcing evidence for differing tau trajectories without explaining their cause. Patient-derived tau filaments seed disease-specific assemblies in mouse brain, while CSF associations and digital-memory findings remain observational; SilencioMA remains an early preclinical lead.