NeuroCIM Research Digest

Johns Hopkins researchers report that the entorhinal cortex and amygdala began shrinking before the hippocampus in scans they analyzed, with greater...

A new study reports that a placenta stem cell nasal spray cut toxic amyloid by more than half and protected memory. These results come from mice, and the report does not describe human testing, so effects and safety in people remain unestablished.

Elevated blood p-tau217 isn't always an Alzheimer's signal. It has also been reported in ALS, and muscle-derived big tau may partly explain this.

In...

Alzheimer's is often pictured as plaques and tangles, but this review frames it as a network of interacting processes. Key threads include:

-...

The PsychAD Consortium combines human genetics with single-cell data to show which genes risk variants affect and in which brain cell types those...

The blood-brain barrier may act as an "intelligent interface" that selects proteins from the blood, according to Gladstone's Andrew Yang. In mice, 92...

A large PET study of living patients links age of onset to differences in tau patterns:

• Those diagnosed before 65 tend to show more widespread tau...

The Mount Sinai Brain Clearance Symposium brings together clinicians and researchers across several disciplines to examine emerging brain...

Some people over 90 stay sharp despite heavy Alzheimer's changes, while others decline with little disease evidence. A newly described grant project...

Bram Goorden, CEO of IXICO, argues that precision medicine is the next frontier for neuroscience. He links past Alzheimer's trial failures to late...

The blood-brain barrier is described as importing diverse neuroprotective molecules, with peripheral apolipoprotein A1 (APOA1) offered as one...

The authors argue that therapies hitting both amyloid and tau could matter most, since current efforts target one or the other. SilencioMA is designed...

The article describes mitochondrial dysfunction as an upstream driver of Alzheimer's, calling it a core hypothesis supported by what it describes as...

Mitochondria-derived vesicles, or mtVs, may help spread Alzheimer's pathology. Here is what the study supports:

• Patient tissue: Release of mtVs is...

A local patient in Owen Sound received a first infusion of donanemab. Previously, starting treatment meant travelling to London Health Sciences, and...

The article presents rasagiline as a gentler, once-daily alternative to selegiline, but its own data point to modest effects.

• Trial benefit: In the...

Digital memory tests may flag subtle early changes, but the authors stress that validation must come first.

• Vanderlip's analysis of AHEAD and A4...

Researchers at UVA Health report that the Alzheimer's risk gene CASS4 may help brain immune cells clear harmful material. When CASS4 function was...

A reported link between high-dose influenza vaccination and lower Alzheimer's risk doesn't show prevention. Dr. Darren Gitelman notes that no studies...

The authors argue that the rarity and transient nature of neurotoxic amyloid-β intermediates have obscured their identity and formation routes in the...