************Topical & oral spironolactone advances for acne and alopecia** [developing]** [developing]** [developing]** [developing]** [developing]** [developing]
Key Questions
What are the benefits of oral spironolactone for women's acne?
SAFA trials show oral spironolactone effective for women's acne over 12 weeks. It outperforms doxycycline according to recent reviews.
How does topical spironolactone compare to adapalene?
Topical 5% spironolactone gel is effective for hormonal and PCOS-related acne, comparable to adapalene. It's a targeted option for these conditions.
What are the advantages for alopecia treatment?
Oral spironolactone combined with low-dose oral minoxidil reduces hypertrichosis by 65%. Dr. Baldwin's dosing guidelines support its use.
SAFA oral spiro women acne (12wk); topical 5% gel vs adapalene for hormonal/PCOS. Oral+LDOM alopecia 65% less hypertrichosis; Baldwin dosing; outperforms DOXY per review.
Sources (2)
Updated Apr 9, 2026