Charlotte falls 41-9 at No. 9 Ole Miss

Charlotte lost 41-9 at Ole Miss on Sept. 12 after trailing 27-0 at halftime. The 49ers generated 322 total yards and three field goals but no touchdowns; Cole Gonzales passed for 128 yards and threw an interception, while Ole Miss rode Kewan Lacy's two rushing touchdowns. The second half was more competitive, but the result underscored the roster and defensive gap against a ranked SEC opponent.