LISA RCT: resistance training reduces MRI brain 'biological age' in older adults
Key Questions
What did the LISA RCT find about resistance training and brain health in older adults?
The one-year randomized trial (n=309) showed that moderate/heavy progressive resistance training (2–3 sessions/week) reduced MRI-derived brain biological age by 1.4–2.3 years, increased BDNF levels, and lowered inflammatory markers. Heavier loading also improved prefrontal connectivity. This supports 2–3 RT sessions/week for cognitive and longevity benefits.
How often should older adults do resistance training for brain health benefits?
The LISA RCT recommends 2–3 sessions per week of moderate to heavy progressive resistance training. Consistency is key, as reinforced by ACSM meta-analyses prioritizing regular dosing over intensity. Pair with protein supplementation for enhanced muscle performance.
What practical benefits does resistance training offer seniors beyond brain health?
RT helps prevent falls and improves balance, as shown in senior chair exercises. It supports bone health, Parkinson's treatment, and overall mobility. Meta-analyses confirm benefits with adequate protein intake.
One‑year randomized trial (n=309) found moderate/heavy progressive resistance training (≈2–3 sessions/week) reduced MRI‑derived brain biological age by ~1.4–2.3 years, increased BDNF, and lowered inflammatory markers; heavier loading added prefrontal connectivity gains. Reinforced by ACSM metas on RT consistency, protein supp metas, senior practicals (falls/bone), Parkinson's Rx. Practical implication: 2–3 RT sessions/week for cognitive/longevity in older adults. Outstanding: long‑term outcomes, subgroups, PD/community translation.