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Lean Mass Preservation on GLP-1s

Lean Mass Preservation on GLP-1s

Clarification that the '40% lean mass loss' stat is a DXA artifact; real concern is appetite suppression reducing protein intake. Meta-analysis shows ~25% lean mass loss on GLP-1s. Protein targets 1.2-1.6 g/kg and resistance training are non-negotiable. Today's reading reinforced these principles with two deep-dive articles and a protein safety guide. No new paradigm shifts.

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Updated Aug 2, 2026