EULAR 2026 Immunization Guidance; Shingrix dementia risk reduction (mixed evidence); NACI expanded RSV guidance; FDA approves Pfizer Abrysvo for at-risk adults 18-59; BCG vaccine off-target brain benefits; new study shows higher severe RSV risk in younger adults with conditions; mRNA-1345 revaccination data
Key Questions
What does the updated EULAR 2026 immunization guidance recommend?
EULAR emphasizes day-zero planning and Shingrix vaccination for all patients. It aims to improve protection in rheumatology populations through proactive scheduling.
What evidence exists on Shingrix and dementia risk?
A Wales study found Shingrix reduced dementia risk by 24% in nursing home residents, but an England replication study showed no reduction. Experts call for randomized trials to clarify mixed findings.
How has FDA expanded Abrysvo approval for RSV?
FDA approved Pfizer's Abrysvo for at-risk adults aged 18-59, expanding beyond the prior 60+ indication. NACI also broadened guidance to younger high-risk adults, though ACIP recommendations remain pending.
EULAR updated immunization guidance emphasizing day-zero planning and Shingrix for all patients. New evidence: Shingrix reduces dementia risk by 24% in nursing home residents (Wales study), but a new replication study in England found no reduction in dementia risk, highlighting mixed evidence and need for randomized trials. Canadian NACI expanded RSV vaccine guidance to include younger high-risk adults (18+) with specific conditions, plus strong recommendation for 75+. FDA approved Pfizer's Abrysvo RSV vaccine for at-risk adults 18-59, expanding access beyond previous 60+ indication. A study on BCG vaccine shows it can remodel brain immune environment and alter Alzheimer's biomarkers in older adults. A new study finds adults 18-49 with high-risk conditions have 62% higher adjusted risk for severe RSV-related lower respiratory tract disease. New: Phase 3 data on mRNA-1345 revaccination at ~24 months shows immune responses noninferior to primary dose in adults 60+, addressing RSV booster timing.