Insulin Resistance Fasting Guide

Combine trials + expert tips for prediabetes gains:

• 12-14h overnight fast boosts insulin sensitivity & mitochondrial function — key for over-60...

Key mechanism from Molecular Psychiatry study:

• Dopamine D2 and insulin receptors co-localize in the central amygdala to brake desire for...

Prediabetes Outcomes

• 🔥 Glucose Normalization Reduces CV Risk: Normalising blood glucose in prediabetes patients halved the long-term risk of...

Practical protocol for insulin resistance: Cook rice, pasta, or potatoes, then chill to trigger retrogradation—increasing resistant starch—even after...

Emerging trend links gut microbiome dynamics to systemic inflammation, with tools for metabolic health:

• Antibiotic remodeling reduces...

Practical tips for 65yo managing prediabetes via Ramadan-like fasting:

• Mimics time-restricted eating: After 12–16h, insulin drops, fat breakdown...

Caution for gut health seekers: Direct-to-consumer microbiome tests from 7 companies showed inconsistent results on three identical fecal samples.

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Key insights from nutrition expert Dr. Amy Shah on rapid weight loss from GLP-1 meds:

• Does it contribute to bone loss or osteoporosis?
• Who is most at risk?
• How to protect bones while managing weight.
  Vital for older adults pursuing weight loss.

Ditch sugary breakfasts—they spike blood sugar rapidly, trigger excess insulin, and cause crashes like reactive hypoglycemia.

Build stable mornings...

Normalizing blood glucose in prediabetes slashes CV death or heart failure risk by half (HR 0.41 after 20 years).

Key insights from DPPOS & DaQing...

Constrained Energy Model debunks exercise myths: Bodies cap total energy expenditure, compensating for activity by cutting elsewhere like immunity.

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Key findings from new Cochrane Review on IF for overweight/obese adults:

• Analyzed 22 RCTs, 1,995 participants over 6-12 months
• 8-hour eating...

Key mechanism from mouse study:

• Obese microbiota elevates gut permeability.
• Recipient mice show risen fasting insulin and HOMA-IR.
• This signals...

Key breakthrough for diabetic surgery patients:

• Standardized protocol embedded in EHR significantly improved intraoperative glucose control and...

Exercise Benefits for Prediabetes and T2D

• 🔥 Physical Activity in Elderly Prediabetes: Elderly individuals with pre-diabetes who were physically...

Emerging RCT trends in TRE/IF for cardiometabolic health:

• eTRE + exercise superior for glucoregulatory outcomes vs other TRE/CR in 40 trials (3259...

Gut microbiome influences insulin resistance via glucose metabolism:

• GLP-1 therapy effects: Gut bacteria, inflammation, and motility shape...

TRF for sustainable insulin gains: Pick 8-10h daily window (e.g., 10AM-6PM) to align circadian rhythm and boost sensitivity without calorie cuts.
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• 12-week calisthenics improved HbA1c (9.60±1.25 to 6.54±0.92, p<0.001), BMI (26.51±3.45 to 24.45±2.98, p=0.007), SBP (136 to 116 mmHg, p<0.001), and...

Key risks for insulin resistance and prediabetes:

• Boosts insulin resistance, complicating blood glucose control.
• Triggers muscle loss then fat...