Dementia Prevention Digest

The Prime Minister announced a £48 million industry partnership to speed dementia research and help promising treatments reach patients faster by...

Similar brain tissue patterns in dogs with cognitive dysfunction and humans with Alzheimer’s suggest shared dementia biology, though this early mapping study offers no insights on prevention or treatment.

Challenging memory tests are highlighted as a way to support earlier Alzheimer’s diagnosis, as the field shifts with disease-modifying therapies. Results must still be paired with biomarkers and full clinical evaluation.

A $1.85 million grant from the Flinn Foundation will support three years of research into new blood-based biomarkers at Banner Sun Health Research...

Alzheimer’s pathology alone often fails to explain all dementia symptoms, as vascular damage and other protein deposits frequently coexist.

• A new...

Visceral fat markers like METS-VF and BRI link to higher all-cause, vascular, and Alzheimer’s dementia risk more than BMI. Yet this observational UK...

Two approaches highlight the push toward pre-symptomatic detection:

• EVP RNA analysis isolates vesicles from blood to track RNA shifts that may...

A small observational study links high-dose vitamin D to better cognitive scores in people with mild impairment—but reveals little about dementia...

Preliminary findings from the AVB-101 trial highlight both promise and open questions for FTD-GRN gene therapy.

• Biomarker response: Dose-dependent...

• Older adults facing food insecurity in later life showed roughly twice the odds of probable dementia versus those with reliable access.
• Mid-life...

Ron Carr's experience with three health notifications shows emerging tests can flag Alzheimer’s risk for ordinary people, but these alerts are best treated as starting points for full clinical assessment rather than definitive forecasts.

Observational studies often mislead on prevention by confusing lifestyle with treatment effects.

• Headlines claiming statins or HRT cut Alzheimer’s...

New research shows starting Alzheimer's treatments earlier boosts lifetime social value by 32%, reaching $138,300 per person through extended...

Blocking PD-1/PD-L1 in an Alzheimer’s mouse model restored microglial homeostasis, cleared smaller amyloid plaques, and reduced neuronal...

Protective genes may help some APOE4 carriers avoid Alzheimer's entirely, showing that carrying the variant does not determine one's future....

Medication side effects and delirium frequently cause dementia misdiagnoses that alter lives.

• A bank clerk diagnosed with Alzheimer’s regained...

Can HRT protect against dementia? Research leaves the question unresolved.

Key factors:

• Timing and formulation appear critical to any potential...

Alzheimer's disease faces a major therapeutic obstacle because the blood–brain barrier severely restricts central nervous system access. Nose-to-brain...

In early symptomatic cognitive impairment consistent with AD, plasma biomarker results may discord with the clinical diagnosis when Lewy body...

Researchers are studying families with rare genetic predispositions to dementia to explore new ways to predict, treat, or prevent Alzheimer's. This...