Lupus Insight Hub

• Rapid CLASI improvements seen within 4-12 weeks across refractory CLE cases.
• Steroid-sparing effect notable, with 50% in one cohort stopping...

MSCs could restore immune balance in SLE by increasing regulatory T and B cells while curbing overactive B and T cells.

• Effects hinge on the...

Low hydroxychloroquine intake and blood levels are tied to higher ASCVD risk in lupus. Consistent use and blood monitoring may therefore protect cardiovascular health beyond flare prevention.

The PMC article on advances and unmet needs in lupus management could not be retrieved.

Adicet's off-the-shelf gamma delta CAR-T prula-cel produced DORIS remission in 54% of 22 heavily pretreated lupus patients at 12 months after one...

Did enpatoran fail biologically, or did WILLOW’s design fail to measure it?

• Dose-response plateaued at 58-49-49% across ascending doses, yet...

A free downloadable template turns complex lupus regimens into one clear, reviewable record by drug class, with doses, indications, and monitoring...

Nkarta's November ACR 2026 presentations on myositis, scleroderma and program-wide safety could clarify whether its off-the-shelf CD19-targeted CAR NK...

Local chef Latasha Adams, living with lupus for 27 years, raised $3,502 for the Greater Ohio Chapter annual walk—more than triple her $1,000 goal. Her...

Eiss Arina, the 25-year-old "waterfall girl," keeps hiking, diving, and chasing monthly waterfall goals even after her 2019 lupus diagnosis and later...

Patients with autoimmune diseases are at an increased risk of cancer due to underlying dysregulation of the immune system or treatment. This connection highlights why tracking individual risk factors remains critical.

Across cities, local lupus walks are channeling individual experiences into awareness, support, and fundraising.

• Dallas walker Sheronda Blanton,...

SLE plasma activates cGAS/STING in HRGECs via self-DNA, driving aberrant glycolysis whose lactate product lactylates and destabilizes EZH2,...

The MHRA's September 2026 authorization allows obinutuzumab for adults with moderate-to-severe, autoantibody-positive SLE on standard therapy.

• Trial...

• Hydroxychloroquine timeline: Expect 2-3 months for initial skin improvement, with full evaluation at 3-6 months; acute CLE responds faster than...

Only the cutaneous lupus study among this week's autoimmune trials produced a direct lupus finding—and it missed its primary endpoint on CLASI-A score...

Neda Amiri Rad witnessed her mother's two-year diagnostic delay for rheumatoid arthritis, which allowed the disease to advance to wheelchair...

Saturday’s Walk to End Lupus Now in DC offers connection and purpose, but weather planning helps everyone participate safely.

• Sun protection first:...

In rheumatic diseases like lupus, sympathetic overactivity and vagal dysfunction impair cortisol regulation and block acetylcholine's...

Women with autoimmune diseases such as lupus achieved 14 pregnancies and 8 healthy births after CAR T-cell therapy, with no complications or disease...