Lupus Insight Hub

Canterbury junior setter Sophia Miller has become her program's all-time assists leader with over 1,000 while guiding teammates on the court....

A little-known protein called FAM76B acts as the gatekeeper for macrophages digesting apoptotic cells via autophagy; without it, ISG15 rises, cleanup...

Lupus patients should pay attention to thrombosis risks because observational studies associate hydroxychloroquine use with reduced thrombotic events and improved survival.

一级亲属患狼疮或其他自身免疫疾病的风险更高。

VA按DC 6350评估SLE，需比较发作频率与器官残留评级，取较高者。

• 记录每年发作次数、持续时间与整体健康损害
• 列出肾脏、关节、皮肤、神经等器官受累及用药
• 对比DC 6350与残留系统评级，准备证据地图

此为患者材料准备参考，非医疗或法律意见。

2026年9月19日，数千名参与者将齐聚伯纳姆公园南区举办“终结狼疮”步行活动，为研究筹款并支持患者。活动从林肯公园移至南区，旨在提升对疾病的认知。

• 疾病负担：黑人女性系统性红斑狼疮患病率达230.9/10万，远高于白人女性的84.7/10万。
• 健康差距：黑人患者平均寿命比白人患者短10年以上，且歧视经历与炎症标志物升高相关。
• 全国行动：此活动是覆盖60座城市的全国系列之一，支持150万美国患者。

A highly prevalent lupus risk haplotype boosts IRF7-dependent IFN-α induction, enhancing antiviral protection while exacerbating autoimmunity. This...

Lupus-risk variants may have been preserved through evolution because they strengthen antiviral immunity. The IRF7-linked haplotype boosts IFN-α...

Serum metabolomics in 58 SLE patients revealed distinct metabolite signatures tied to lupus nephritis, active disease, remission, and glucocorticoid...

Beeline's afimetoran met its primary endpoint with higher SRI-4 rates at week 48 across all three doses versus placebo (p<0.001) in 248 adults with...

Recurring joint pain without injury is a key reason to see a rheumatologist.

• Watch for: Joint swelling, facial rashes, mouth ulcers, hair loss,...

A-319, a CD3×CD19 T-cell engager, delivered complete B-cell depletion and 60% DORIS remission at 12 months in refractory SLE with no serious adverse events or high-grade CRS. This off-the-shelf approach could expand access beyond CAR-T barriers.

Positive topline results from the Phase 2 trial show afimetoran meeting its primary endpoint with significantly higher SRI-4 response rates versus...

In a 36-year-old woman, psychosis initially attributed to primary psychiatric illness—alongside recent surgical management of pericardial...

The FDA's RMAT designation for obe-cel in SLE and lupus nephritis offers an accelerated development pathway for this CAR-T therapy in serious...

• Protection level: Updated 2023-2024 shot tied to 69% lower hospitalization odds versus no vaccination.
• Practical step: Bring up the updated shot...

Lupus patients face a paradox where immune overactivity drives autoimmunity yet often coexists with impaired protection against infections.

• Shared...

This foundational study found that IgG from some SLE patients protects 35-45 base pair DNA fragments from DNase digestion through monogamous bivalent...

Idaho's Walk to End Lupus Now turns local awareness into direct action by raising funds for research, education, and patient services while giving...

Beeline Medicines' promising mid-stage results for a repurposed Bristol Myers Squibb lupus candidate highlight how shelved assets can advance new...