March 25, 2026
Medical Research Compass · Mar 25 Daily Digest
Cancer Therapy Breakthroughs
- 🔥 UTSW-InterAct Gene Therapy Licensing: UTSW Southwestern Medical Center and InterAct Therapeutics announced an...
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Medical Research Compass
Created by Bethan Herrman
Peer‑reviewed clinical trials, breakthrough treatments, public‑health guidance, and lifestyle prevention for cancer, heart, brain health
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Explore the latest content tracked by Medical Research Compass
March 25, 2026
UCLA's iNKT Stem Cell Platform: Universal CAR-T for Cancer
Unconventional breakthrough in scalable cancer immunotherapy:
- Off-the-shelf iNKT cells from cord blood stem cells, engineered by Lili Yang at UCLA
-...
March 25, 2026
Oncology Trials Trend: Time Burdens vs. Access Innovations
- Heavy patient load: Phase 2 cancer trials require a median 13 research days, averaging 1 visit every 8 days and consuming 10.5% of median PFS.
-...
March 25, 2026
GLP-1 Trends: Women Lose More Weight Than Men, Retatrutide Delivers 17% Loss
Key developments in GLP-1 weight loss therapies:
- Sex differences: Women lost ~11% body weight vs 7% for men in meta-analysis of >40 RCTs.
- Theories...
March 25, 2026
Vitamin B3 Targets miR-93 in Fatty Liver Breakthrough
MASLD epidemic: Affects 30% globally, long lacking targeted therapies.
- miR-93 culprit: Elevated levels suppress SIRT1, driving fat buildup,...
March 25, 2026
Obamacare Wars Sparked Erosion of Science Trust in COVID Era
The brutal fight over Obamacare ignited a culture war that eroded public trust in science, fueling pandemic skepticism.
Key shifts:
- ACA success...
March 25, 2026
Tau PET Reveals Symptom Links in Huntington's Disease
Tau PET imaging uncovers associations between tau pathology and clinical symptoms in pre-manifest and early Huntington's disease (HD).
Key...
March 25, 2026
EHR Emulation Links ACE Inhibitors to Higher Dementia Risk
- Rapid repurposing test: Emulated target trial with EHR data from Mass General Brigham, comparing ACEi vs ARBs in 25,507 patients aged 50+ using IPTW...
March 25, 2026
TAVI Breakthroughs for Rising Youth Heart Disease
Dr. Tanmay Kulkarni highlights TAVI as a game-changing, minimally invasive valve implant avoiding open-heart surgery.
- Youth surge: Heart disease...
March 25, 2026
Cancer Genomics Trend: From Broad Insights to Myeloma GEP Precision
Key trend in patient education on precision diagnostics:
- General cancer genomics covers mutations, gene expression, and tumor microenvironment,...
March 24, 2026
Medical Research Compass · Mar 24 Daily Digest
Neurodegenerative Therapy Milestones
- 🔥 FDA Priority Review for Zilganersen in Alexander Disease: FDA accepted Ionis' zilganersen NDA for...
March 24, 2026
CAR-T Trend: Metabolic Innovations and Real-World Rollout for Blood Cancers
Key trend in CAR-T expansion for hematologic malignancies:
- Metabolic-tracking 'bloodhounds' enhance immune targeting of cancer cells
- Transformed...
March 24, 2026
Zilganersen's Breakthrough Path for Alexander Disease
FDA priority review accepted for zilganersen NDA, with PDUFA target Sept 22, 2026—accelerating first potential therapy for AxD.
- Pivotal trial met...
March 24, 2026
Lithium for Alzheimer's: New Doubts Emerge
- Lithium deficiency linked to Alzheimer’s onset in 2025 Nature study.
- Creator grows more cynical on prior hype, urges scrutiny of evidence.
- Mixed...
March 24, 2026
Inspirational Visions: Robust Institutions and Lifelong Public Health Commitment
Two visions inspire stronger public health protections:
- Remake institutions into effective authorities, resilient to industry capture and focused on...
March 24, 2026
Rapid Advances in Lung Cancer Targeted Therapies from 2026 Conferences
Key trends from recent meetings signal fast-evolving targeted therapies:
- Molecular complexity rising: EGFR-mutant cases often show multiple...
March 24, 2026
Life Course Epidemiology: Cumulative Exposures Across Lifespan
Cumulative exposures layer over a lifetime to shape health outcomes, not just present conditions.
Key models:
- Critical periods: Exposures in...
March 24, 2026
AI's Cutting-Edge Role in Early Alzheimer's Prediction
Key advances in AI for neurodegenerative diagnostics:
- Multimodal integration: Combines genetics, biomarkers like amyloid markers, and cognitive data...
March 24, 2026
7,000 Steps a Day: The Evidence-Based Target for Longevity and Heart Health
Challenging the 10,000 steps myth—new evidence shows fewer steps deliver major benefits:
- Harvard study of 18,000 women (age 72): 4,400 steps/day cut...
March 24, 2026
Quick Guide to Cancer Clinical Trials Basics
Access innovative cancer treatments via clinical trials – research studies testing new therapies. A concise 2:21 video outlines benefits of participation; dive deeper at cancer.org/clinicaltrials.