Retina Expert Brief

AMD Research

• 🔥 AREDS and AREDS2 are high-dose nutritional supplements developed through large clinical trials to slow the progression of AMD.
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• Humor-driven outreach: Genentech partners with diaTribe and Damon Wayans to normalize DME discussions via comedy and personal storytelling.
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Choroidal structure may predict macular changes and visual outcomes after panretinal photocoagulation in advanced diabetic retinopathy.

AREDS and AREDS2 are high-dose nutritional supplements developed through large clinical trials to slow the progression of AMD.

Ginsenoside Rg3 combined with ranibizumab offers synergistic inhibition of macular vascular permeability in DME by targeting molecular pathways beyond VEGF alone. This points to a promising adjunct for cases with incomplete anti-VEGF response.

Intravitreal anti-VEGF remains first-line therapy for exudative AMD, yet its long-term repetitive use raises questions about longitudinal vascular changes.

Triglyceride-glucose index shows a clearer association with retinal vascular diameter in glucose and lipid metabolism–related diseases.

Gene Therapy Developments

• 🔥 NAAVIGATE Trial: AbbVie's NAAVIGATE trial is evaluating surabgene lomparvovec (sura-vec) as a one-time subretinal...

AbbVie's NAAVIGATE trial evaluates surabgene lomparvovec (sura-vec) as a one-time gene therapy injected into the layer just outside the retina. For...

• Access hurdles persist: Real-world barriers limit anti-VEGF delivery for retinal vascular diseases despite proven vision preservation in wet AMD and...

Deep learning paired with ultra-widefield imaging is being explored to enhance detection of diabetic retinopathy and diabetic macular edema, the leading causes of preventable blindness among working-age adults.

A prospective observational study of 90 patients with AMD or diabetic macular oedema receiving intravitreal aflibercept 2 mg tracks long-term intraocular pressure changes across three groups to guide routine monitoring protocols.

The infographic summarizes efficacy and safety data for high-dose intravitreal aflibercept 8 mg in treatment-naïve neovascular AMD, offering retina specialists key visual and anatomic outcomes to evaluate for extended dosing strategies.

Anti-VEGF-resistant subretinal fluid in AMD is associated with better vision. One key hypothesis ties this to RPE and choriocapillaris damage...

Clinical Trial Results

• 🔥 Brolucizumab vs Laser in PDR: In the CONDOR trial, brolucizumab outperformed panretinal laser photocoagulation in...

Brolucizumab outperformed panretinal laser photocoagulation for proliferative diabetic retinopathy vision outcomes at week 54 in the CONDOR trial.

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AI-based analysis of fundus images enables standardized and reproducible quantification of retinal vascular features, offering consistent metrics that support integration into diagnostic workflows for retina specialists.

This extension study evaluates the long-term efficacy and safety of suprachoroidal triamcinolone acetonide (CLS-TA) in patients with macular oedema, offering critical data on sustained steroid delivery for retinal edema management.

Retinal Detachment Risk After Injection

• 🔥 Demographic Variations in RRD Rates: Overall RRD prevalence after intravitreal injection was 0.66%,...

ARVO 2026 data from Cleveland Clinic reveal clear demographic stratification in rhegmatogenous retinal detachment risk after intravitreal injection,...